TELOMERE THERAPEUTICS IS PIONEERING THE REPAIR OF TELOMERES TO TREAT ORGAN FIBROSIS AND TELOMEROPATHIES
Telomeres are nucleoprotein structures localized at the ends of eukaryotic chromosomes, which are essential to protect them from degradation and end-to-end chromosome fusions. In the adult organism telomeres shorten associated to cellular division. When telomeres reach a critically short length this is insufficient to warrant telomere protection thus leading to the activation of a persistent DNA damage response at chromosome ends, ultimately inducing senescence or apoptosis. Telomere shortening is considered one of the hallmarks of aging as short telomeres have been shown to be sufficient to induce organismal aging.
